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- Thomas D Giles.
- Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA. tgiles4@cox.net
- Am. J. Med. 2010 Jul 1; 123 (7 Suppl 1): S16S20S16-20.
AbstractDespite their proven mortality and morbidity outcomes benefits, beta-blockers remain substantially underused in patients with cardiac conditions. Reluctance to prescribe beta-blockers may be owing to concerns about tolerability with the traditional drugs in this class. Beta-blockers with vasodilatory properties, such as carvedilol and nebivolol, may overcome the tolerability and metabolic issues associated with traditional beta-blockers. Because endothelial dysfunction, the pathophysiologic hallmark of hypertension, may be heightened in populations with difficult-to-treat hypertension (e.g., elderly patients, African American patients), a vasodilating beta-blocker may be a particularly appropriate choice for these patient groups.Copyright (c) 2010 Elsevier Inc. All rights reserved.
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