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- Martín de Santibañes, Rodrigo Sanchez Clariá, Eduardo de Santibañes, Juan Pekolj, and Oscar Mazza.
- Sección Hígado-Vías Biliares-Páncreas, Servicio de Cirugía General, Sección de Trasplante Hepático, Hospital Italiano de Buenos Aires, Argentina. E-mail: martin.desantibanes@hospitalitaliano.org.ar.
- Medicina (B Aires). 2019 Jan 1; 79 (Spec 6/1): 576581576-581.
AbstractLocally advanced pancreatic cancer (LAPC) has several definitions, but it is essentially a non-metastatic tumor, in which the initial surgical resection is not considered beneficial due to the extensive vascular involvement and consequent high chance of a nonradical resection. The introduction of chemotherapy with calcium leucovorin, fluorouracil, irinotecan hydrochloride and oxaliplatin (FOLFIRINOX) and gemcitabine-nab (nanoparticle albumin-bound)-paclitaxel (gem-nab) had very important implications for the management of patients with LAPC. After 4 to 6 months of induction chemotherapy, a large proportion of them have stable disease or even tumor regression, allowing to rescue those who initially were not candidates for surgery, with 30-35 months overall survival after surgery.
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