• Am. J. Med. · Sep 1980

    Does a renal vasodilator system mediate racial differences in essential hypertension?

    • S E Warren and D T O'Connor.
    • Am. J. Med. 1980 Sep 1; 69 (3): 425429425-9.

    AbstractClinical and epidemiologic data support the contention that black people have a higher incidence and severity of essential hypertension than white people, a phenomenon which is likely due to genetic factors. Physiologic profiles in such patients reveal a striking prevalence of low renin, volume-expanded hypertension, with an exaggerated propensity to sodium retention. A deficiency in the natriuretic, vasodilatory renal kallikrein-kinin system may explain these phenomena and may be of practical importance in the selection of therapy.

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