• Dragisa Sljivancanin, Vesna Kesić, Lidija Tulić, and Jelena Dotlić.
• Srp Ark Celok Lek. 2013 Mar 1; 141 (3-4): 192197192-7.

IntroductionPremalignant changes of the uterine cervix occur with similar frequency during pregnancy and in non-pregnant women. Due to the fact that any surgery on the cervix can jeopardize pregnancy, it is important to define the protocol of procedures for the treatment of these changes during pregnancy.ObjectiveThe aim of the study was to investigate the natural course of premalignant cervical changes during pregnancy and the impact of their treatment on the pregnancy course.MethodsStudy involved all patients with colposcopically, cytologically and hystopathologically diagnosed premalignant cervical changes during pregnancy from 2002 to 2008. Patients were divided into two groups according to the applied treatment during pregnancy: surgery or monitoring by regular colposcopic and cytological examinations. The two groups were compared concerning treatment outcome, persistence or regression of changes and pregnancy duration.ResultsStudy involved 58 patients. Spontaneous remission of lesions occurred after pregnancy in 63.79% of cases. High-grade squamous intraepithelial lesion (H-SIL) demonstrated a higher rate of persistency in comparison with low-grade squamous intraepithelial lesion (L-SIL) (X2=25.115; p<0.05). Only one finding of L-SIL progressed into H-SIL in the monitored group. Patients who underwent conization during pregnancy had a significantly more frequent preterm deliveries (X2=14.369; p<0.05).ConclusionThe obtained high rate of spontaneous regression of cervical changes after pregnancy as well as the lower incidence of preterm births in patients who were not treated by conization during pregnancy, confirm that patients with premalignant cervical changes should be, if invasion is excluded, under follow-up throughout pregnancy by regular colposcopic and cytological examinations. Therapeutic conization, due to numerous complications, should be performed only when there is a suspected presence of a more severe form of the disease (micro invasive and invasive carcinoma).

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