• H C Hendrie, A Ogunniyi, K S Hall, O Baiyewu, F W Unverzagt, O Gureje, S Gao, R M Evans, A O Ogunseyinde, A O Adeyinka, B Musick, and S L Hui.
• Department of Psychiatry, Indiana University School of Medicine, 541 Clinical Dr, Room 394A, Indianapolis, IN 46202, USA. hhendri@iupui.edu
• JAMA. 2001 Feb 14; 285 (6): 739747739-47.

ContextAlzheimer disease (AD) represents a major and increasing public health problem. If populations were identified with significantly lower or higher incidence rates of AD, the search for risk factors in the genesis of AD could be greatly enhanced.ObjectiveTo compare incidence rates of dementia and AD in 2 diverse, elderly community-dwelling populations.DesignThe Indianapolis-Ibadan Dementia Project, a longitudinal, prospective population-based study consisting of a baseline survey (1992-1993) and 2 subsequent follow-up waves after 2 years (1994-1995) and 5 years (1997-1998). Each wave followed a 2-stage design, with an in-home screening interview followed by a full diagnostic workup of a subsample of participants based on screening performance.Setting And ParticipantsA total of 2459 community-dwelling Yoruba residents of Ibadan, Nigeria, without dementia, and 2147 community-dwelling African American residents of Indianapolis, Ind, without dementia (all aged 65 years or older). The cohorts were followed up for a mean of 5.1 years and 4.7 years, respectively.Main Outcome MeasuresIncident cases of dementia and AD in each of the 2 populations.ResultsThe age-standardized annual incidence rates were significantly lower among Yoruba than among African Americans for dementia (Yoruba, 1.35% [95% confidence interval [CI], 1.13%-1.56%]; African Americans, 3.24% [95% CI, 2.11%-4.38%]) and for AD (Yoruba, 1.15% [95% CI, 0.96%-1.35%]; African Americans, 2.52% [95% CI, 1.40%-3.64%]).ConclusionThis is the first report of incidence rate differences for dementia and AD in studies of 2 populations from nonindustrialized and industrialized countries using identical methods and the same group of investigators in both sites. Further explorations of these population differences may identify potentially modifiable environmental or genetic factors to account for site differences in dementia and AD.

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