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Clinical Trial
Proton-pump inhibitor as palliative care for chemotherapy-induced gastroesophageal reflux disease in pancreatic cancer patients.
- Tadashi Uwagawa, Takeyuki Misawa, Tomonori Iida, Taro Sakamoto, Takeshi Gocho, Shigeki Wakiyama, Shoichi Hirohara, and Katsuhiko Yanaga.
- Department of Surgery, Jikei University School of Medicine, Tokyo, Japan. uwatadashi@msn.com
- J Palliat Med. 2010 Jul 1; 13 (7): 815818815-8.
AbstractRelief of adverse events induced by chemotherapy is an important issue for patients, especially those with a poor prognosis, such as with pancreatic cancer. There are no reports of the relationship between gastroesophageal reflux disease (GERD) and chemotherapy, so we investigated the incidence of chemotherapy-induced GERD in patients undergoing treatment with gemcitabine or S-1 for pancreatic cancer and the effect of sodium rabeprazole (RPZ), a proton-pump inhibitor. GERD was diagnosed in 40% of the patients according to the Frequency Scale for Symptoms of GERD score, and RBZ therapy significantly improved their symptoms.
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