• Am J Emerg Med · Feb 2010

    Case Reports

    Cardiogenic shock associated with reversible dilated cardiomyopathy during therapy with regular doses of venlafaxine.

    • Jean-Christophe Charniot, Noelle Vignat, Jean-Jacques Monsuez, Rachid Kidouche, Boryana Avramova, Jean-Yves Artigou, and Jean-Paul Albertini.
    • AP-HP Avicenne Hospital, Department of Cardiology, Université Paris 13, UFR SMBH, 125 Route de Stalingrad, 93009 Bobigny Cedex, France. jean-christophe.charniot@avc.aphp.fr
    • Am J Emerg Med. 2010 Feb 1; 28 (2): 256.e1256.e2565256.e1-5.

    AbstractWe report a cardiac complication in a patient treated with regular doses of venlafaxine. A 49-year-old man with prior normal cardiac function and stable chronic hepatitis C was treated for a major depressive disorder with usual doses of venlafaxine during an 8-month period until the occurrence of a cardiogenic shock in a context of dilated cardiomyopathy. Three months after withdrawal of the drug, the left ventricular ejection fraction returned to normal values. Cardiomyopathy is a rare complication with high doses of venlafaxine that was not previously reported in patients free of prior cardiac disease and cardiomyopathy and treated with usual doses (initially 150 mg daily; after 3 months, 75 mg daily). An objective assessment revealed that venlafaxine was probably implied in the subsequent development of cardiomyopathy when considering the Naranjo Probability Scale. Physicians who usually prescribe venlafaxine have to be briefed on such potential cardiac adverse effects even with usual doses.Copyright 2010 Elsevier Inc. All rights reserved.

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