• Medical hypotheses · Aug 1991

    Is natural progesterone the missing link in osteoporosis prevention and treatment?

    • J R Lee.
    • Med. Hypotheses. 1991 Aug 1;35(4):316-8.

    AbstractConventional treatment with vitamin D, calcium, and estrogen will delay but not reverse osteoporosis. The addition of fluoride may increase bone mass but fails to increase bone strength; fracture incidence is actually increased in non-vertebral bone by fluoride. Clearly, successful treatment of osteoporosis remains an unsolved problem. In women, osteoporosis coincides with menopause. The hypothesis that progesterone and not estrogen is the missing factor was tested in a clinical setting and was found to be extraordinarily effective in reversing osteoporosis.

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