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- B Simorre, E Braun, A Dubois, I Quéré, S Yeche, D Reynaud, and C Janbon.
- Service de médecine interne B, hôpital Saint-Eloi, 2, avenue Bertin-Sans, 34295 Montpellier, France. bernard.simorre@wanadoo.fr
- Rev Med Interne. 2002 Apr 1; 23 (4): 390393390-3.
IntroductionPolyarteritis nodosa is a systemic necrotizing vasculitis that may become serious, even with no usual poor prognosis factors.ExegesisWe report two cases of polyarteritis nodosa with negative histology, starting only with an extensive necrosis of the extremities. The treatment, associating corticosteroids and, secondarily, immunosuppressors, did not prevent a bilateral half-leg amputation for the two patients. In the first case the disease stabilized, but in the second one, it worsened, leading to death within 2 years.ConclusionThis clinical aspect of the disease is unusual and should be identified because of its bad prognosis. It might benefit from a treatment from the outset associating corticosteroids and immunosuppressors, even with no usual bad prognosis factors.
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