• C Cazalets, E Laurat, B Cador, F Jan, Y Rolland, P Jégo, and B Grosbois.
• Service de médecine interne, hôpital Sud, 16, boulevard de Bulgarie, BP 5612, 35056 cedex 02, Rennes, France. francoise.robert@chu-rennes.fr <francoise.robert@chu-rennes.fr>
• Rev Med Interne. 2003 Feb 1; 24 (2): 127130127-30.

IntroductionThe responsibility of cannabis in juvenile thromboangeitis has been suggested for few years. We describe four new cases.ExegesisYoung men presented with distal arteriopathy of the lower limbs in 3 cases, and of the left upper limb in the remaining patient. Symptoms occurred progressively, distal pulses had disappeared, and distal necrosis was constant. Three patients suffered from Raynaud phenomenon, none of them presented with venous thrombosis. Radiologic evaluation revealed distal abnormalities in all cases, and proximal arterial thrombosis in one case. The four patients were cannabis smokers for at least four years. With cannabis interruption and symptomatic treatment, lesions improved for three patients. For one of them, recurrence of arteriopathy occurred when he resumed to smoke cannabis. For the fourth one who never stopped cannabis, an amputation was necessary.ConclusionSearch for cannabis use is important because interruption may improve prognosis.

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