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Review Meta Analysis
Angiotensin receptor blockers and breast cancer risk: a meta-analysis.
- Yun-Feng Qian, Wei-Guo Xu, and Jun Wu.
- Department of Geriatrics, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China - qianyunfgz@tom.com.
- Panminerva Med. 2017 Sep 1; 59 (3): 269273269-273.
IntroductionSome studies reported that angiotensin receptor blockers (ARBs) reduced the risk of breast cancer. However, other studies did not show similar results.Evidence AcquisitionThe PubMed and EMBASE databases were searched. The strength of the association between ARBs and the risk of breast cancer was measured by odds ratio (OR) and 95% confidence interval (CI).Evidence SynthesisEight eligible studies with 1,994,880 individuals were considered for this meta-analysis. ARBs was not associated with the risk of breast cancer (OR=0.93; 95% CI: 0.81-1.06; I2=86%). In the subgroup analysis of race, a significantly decreased breast cancer risk were observed in Asians (OR=0.62; 95% CI: 0.53-0.73; I2=0%). However, a significantly increased breast cancer risk were observed in Caucasians (OR=1.08; 95% CI: 1.02-1.13; I2=28%).ConclusionsThis study provided evidence that ARBs was associated with decreased breast cancer in Asians and increased risk of breast cancer in Caucasians.
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