• J. Korean Med. Sci. · Jul 2011

    FCεRI gene promoter polymorphisms and total IgE levels in susceptibility to atopic dermatitis in Korea.

    • Kui Young Park, Mi Kyung Park, Eun Joo Kim, Mi-Kyung Lee, and Seong Jun Seo.
    • Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
    • J. Korean Med. Sci. 2011 Jul 1; 26 (7): 870874870-4.

    AbstractIgE-dependent activation of mast cells and basophils through the high-affinity IgE receptor (FcεRI) is involved in the pathogenesis of allergen-induced immune responsiveness in atopic diseases like atopic dermatitis (AD). We sought to determine FcεRI gene polymorphisms are associated with AD in Korean patients, and analyzed the relevance of FcεRI gene polymorphisms and serum IgE levels. We conducted a case-control association analysis (175 patients and 56 controls) of Korean subjects. Genotyping was performed using the TaqMan fluorogenic 5' nuclease assay, and serum levels of IgE were measured using a fluorescence enzyme immunoassay. We found that there were no significant relationships between FcεRI and AD, although there were trends towards an association between the 66T>C (rs2251746) polymorphism and total serum IgE levels in the Korean AD patients. In conclusion, while the 66T>C (rs2251746) of the FcεRIα polymorphism may be linked to AD and higher serum IgE levels, polymorphisms in the FcεRIβ gene did not confer susceptibility to AD in our patient sample.

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