• Guang Jin, Hyo-Sung Jeon, Eung Bae Lee, Hyo-Gyoung Kang, Seung Soo Yoo, Shin Yup Lee, Jae Hee Lee, Sung Ick Cha, Tae In Park, Chang Ho Kim, Sang Hoon Jheon, and Jae Yong Park.
• Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine, Daegu, Korea.
• J. Korean Med. Sci. 2012 Feb 1; 27 (2): 228230228-30.

AbstractA fusion gene between echinoderm microtubule-associated protein-like 4 (EML4) and the anaplastic lymphoma kinase (ALK) has been identified in non-small cell lung cancers (NSCLCs). Although a few studies have evaluated EML4-ALK fusion genes in Korean NSCLCs, the prevalence of different EML4-ALK fusion variants has yet to be clearly assessed. Herein, we have examined the profiles of EML4-ALK fusion gene variants in Korean patients of NSCLCs. EML4-ALK fusion genes have been detected in 10 (6.0%) of 167 patients of NSCLCs and in 9 (7.4%) of 121 patients of adenocarcinoma. Of the 10 patients with fusion genes identified, 8 (80%) were E13;A20 (variant 1) and 2 (20%) were E6;A20, with an additional 33-bp sequence derived from intron 6 of EML4 (variant 3b). These results indicate that the profiles of EML4-ALK fusion gene variants in Korean patients of NSCLC may differ from those in other ethnic populations. Herein, we describe for the first time the profiles of EML4-ALK fusion variants of Korean patients with NSCLCs.

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