• Jae Yeon Lee, Seung Soo Yoo, Hyo-Gyoung Kang, Guang Jin, Eun Young Bae, Yi Young Choi, Jin Eun Choi, Hyo-Sung Jeon, Jaehee Lee, Shin Yup Lee, Seung-Ick Cha, Chang Ho Kim, and Jae Yong Park.
• Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
• J. Korean Med. Sci. 2012 Dec 1; 27 (12): 153615401536-40.

AbstractA genome-wide association study has identified the 15q25 region as being associated with the risk of chronic obstructive pulmonary disease (COPD) in Caucasians. This study intended as a confirmatory assessment of this association in a Korean population. The rs6495309C > T polymorphism in the promoter of nicotinic acetylcholine receptor alpha subunit 3 (CHRNA3) gene was investigated in a case-control study that consisted of 406 patients with COPD and 394 healthy control subjects. The rs6495309 CT or TT genotype was associated with a significantly decreased risk of COPD when compared to the rs6495309 CC genotype (adjusted odds ratio = 0.69, 95% confidence interval = 0.50-0.95, P = 0.023). The effect of the rs6495309C > T on the risk of COPD was more evident in moderate to very severe COPD than in mild COPD under a dominant model for the variant T allele (P = 0.024 for homogeneity). The CHRNA3 rs6495309C > T polymorphism on chromosome 15q25 is associated with the risk of COPD in a Korean population.

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