• Larissa Avilés-Santa, Karin Salinas, Beverley Adams-Huet, and Philip Raskin.
• Department of Medicine, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd G5.238, Dallas, TX 75390-8858, USA. Maines.Aviles-Santa@UTSouthwestern.edu
• J. Investig. Med. 2007 Jan 1; 55 (1): 111711-7.

ObjectiveTo evaluate the effects of insulin in multiple daily injections (MDI) on peripheral glucose disposal in Latin American patients with type 2 diabetes.Methods And ResultsTen Latin American patients (four men and six women) with type 2 diabetes between the ages of 32 and 45 years were evaluated. All women were premenopausal and had regular menstrual periods. A hyperinsulinemic-euglycemic clamp procedure was performed at baseline and was repeated approximately 2 years after insulin monotherapy on MDI was initiated. Both genders had comparable baseline anthropometric and laboratory features, including a mean body mass index > 30 kg/m2 and percent body fat > 30%. Baseline percent hemoglobin A1c (HbA1c%) was 9.5 +/- 1.5%, and post-intervention HbA1c% was 7.0 +/- 1.2%. The peripheral glucose disposal rate at baseline was 4.5 +/- 2.2 mg/kg/min fat-free mass and at postintervention was 3.6 +/- 2.3 mg/kg/min fat-free mass.ConclusionsDespite a significant improvement in glycemic control, MDI did not seem to increase the insulin-mediated glucose disposal rate. Underlying obesity and increased percent body fat may have been the most counteracting factors on the potential improvement in insulin sensitivity expected with insulin monotherapy.

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