-
Chinese Med J Peking · Mar 2003
The potential role of IGF-I receptor mRNA in rats with diabetic retinopathy.
- Hongyu Kuang, Wei Zou, Dan Liu, Rongxing Shi, Lihua Cheng, Huiqing Yin, and Xiaomin Liu.
- Department of Endocrinology, First Clinical Hospital of Harbin Medical University, Harbin 150001, China. kuangzou@public.hr.hl.cn
- Chinese Med J Peking. 2003 Mar 1; 116 (3): 478480478-80.
ObjectiveTo evaluate the potential role of insulin-like growth factor-1 receptor mRNA (IGF-IR mRNA) in the onset and development of retinopathy in diabetic rats.MethodsA diabetic model was duplicated in Wistar rats. The early changes in the retina were examined using light and transmission electron microscopy. Expression of IGF-IR mRNA was analyzed using in situ hybridization.ResultsWeak expression of IGF-IR mRNA (5%) was found in retinas of normal rats, but was significantly increased (15% and 18%) in the retinas of diabetic rats after 3 and 6 months of diabetes (P < 0.01). In situ hybridization and morphological study demonstrated that there was a positive correlation between IGF-IR mRNA expression and retinal changes at various stages.ConclusionIncreased IGF-IR mRNA might play an important role in the onset and development of diabetic retinopathy.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..