• Chinese Med J Peking · Aug 2003

    Inhibiting severe acute respiratory syndrome-associated coronavirus by small interfering RNA.

    • Renli Zhang, Zhongmin Guo, Jiahai Lu, Jinxiu Meng, Canquan Zhou, Ximei Zhan, Bing Huang, Xinbing Yu, Min Huang, Xinghua Pan, Wenhua Ling, Xigu Chen, Zhuoyue Wan, Huanying Zheng, Xinge Yan, Yifei Wang, Yanchao Ran, Xinjian Liu, Junxin Ma, Chengyu Wang, and Biliang Zhang.
    • Sun Yat-Sen University, Guangzhou 510089, China.
    • Chinese Med J Peking. 2003 Aug 1; 116 (8): 126212641262-4.

    ObjectiveTo evaluate the effectiveness of small interfering RNA (siRNA) on inhibiting severe acute respiratory syndrome (SARS)-associated coronavirus replication, and to lay bases for the future clinical application of siRNA for the treatment of viral infectious diseases.MethodsVero-E6 cells was transfected with siRNA before SARS virus infection, and the effectiveness of siRNA interference was evaluated by observing the cytopathic effect (CPE) on Vero-E6 cells.ResultsFive pairs of siRNA showed ability to reduce CPE dose dependently, and two of them had the best effect.ConclusionsiRNA may be effective in inhibiting SARS-associated coronavirus replication.

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