• Boxun Zhang, Rensong Yue, Xiaoying Huang, Ying Wang, Yayi Jiang, and Jiawei Chin.
• Hospital of Chengdu University of Traditional Chinese Medicine.
• Medicine (Baltimore). 2019 Dec 1; 98 (50): e18346e18346.

BackgroundType 2 diabetes (T2D) is a significant health concern worldwide, and good glycemic control is the basis of avoiding disease progression. Herbal tea, as a convenient and effective medication method, has gained popularity among many diabetic patients. However, there are no systematic reviews or meta-analyses to evaluate the clinical efficacy of herbal tea on T2D.MethodsFour English electronic databases and 4 Chinese electronic databases were searched for randomized controlled trials (RCTs) meeting inclusion criteria; Clinical trials were searched to explore the relevant unpublished data. Fasting blood glucose and glycated hemoglobin will be measured as primary outcomes. Secondary outcomes include 2-hour postprandial blood glucose, fasting insulin, and homeostasis model assessment-insulin resistance. The heterogeneity of data will be investigated by Chi-square and I test; subgroup analysis and sensitivity analysis will be conducted to explore the sources of heterogeneity; funnel plot will be used to evaluate publication bias; finally, we will use grading of recommendations assessment, development, and evaluate system method to evaluate the quality of evidence. Merging analysis of data will be performed using Rev Man 5.3 software.ResultsThe results will be published in a peer-reviewed journal.ConclusionsThe systematic review will confirm whether herbal tea consumption is benefit to the glycemic control in patients with T2D.Prospero Registration NumberCRD42019129863.

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