• Hongling Wang, Guoying Zhou, Linjie Luo, CrusiusJ Bart AJBA, Anlong Yuan, Jiguang Kou, Guifang Yang, Min Wang, Jing Wu, von BlombergB Mary EBME, Servaas A Morré, A Salvador Peña, and Bing Xia.
• From the Department of Gastroenterology, Zhongnan Hospital of Wuhan University, and Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases, Wuhan (HW, GZ, LL, BX); Department of Gastroenterology, Xiaogan Central Hospital, Xiaogan (AY, JK); Department of Pathology, Zhongnan Hospital of Wuhan University (GY); Department of Pathology, Basic Medicine School of Wuhan University, Wuhan University, Wuhan (MW); Department of Gastroenterology, Jiangsu Provincial Hospital of TCM, Nanjing (JW); Medical Immunology, Department of Pathology, VU University Medical Center, Amsterdam (BMEVB); and Laboratory of Immunogenetics at the Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands (JBAC, SAM, ASP).
• Medicine (Baltimore). 2015 Oct 1; 94 (42): e1779e1779.

AbstractCeliac disease (CD) is common in Caucasians, but thought to be rare in Asians. Our aim was to determine the prevalence of CD in Chinese patients with chronic diarrhea predominant irritable bowel syndrome (IBS-D).From July 2010 to August 2012, 395 adult patients with IBS-D and 363 age and sex-matched healthy controls were recruited in Zhongnan Hospital of Wuhan University and Xiaogan Central Hospital in Hubei province, central China. Patients with IBS-D were diagnosed according to the Rome III criteria. Serum Immunoglobulin (IgA/IgG) anti-human tissue transglutaminase (anti-htTG)-deamidated gliadin peptide (DGP) antibodies were measured in a single ELISA (QUANTA Lite h-tTG/DGP Screen). Upper endoscopy with duodenal biopsies and HLA-DQA1 and HLA-DQB1 genotyping were performed in seropositive subjects and a gluten-free diet was prescribed.Seven IBS-D patients (7/395, 1.77%) and 2 healthy controls (2/363, 0.55%), were positive for anti-htTG/DGP antibodies. Of these 9 cases, 1 was lost to follow-up, 3 were suspected to have CD and 5 were eventually diagnosed as CD with intestinal histological lesions classified as Marsh Type II in 2 and Type III in 3. Of these 5 diagnosed CD patients, 4 (4/395, 1.01%) were from the IBS-D group and 1 (1/363, 0.28%) from the healthy control had asymptomatic CD. Two Type III CD patients with relatively high titers in the serologic assay were homozygous and heterozygous for haplotype HLA-DQA1*03-DQB1*03:03 (HLA-DQ9.3), respectively.In the present study, CD was present in 1.01% of patients with IBS-D and in 0.28% of the control group. We like to suggest that the haplotype HLA-DQA1*03-DQB1*03:03 (HLA-DQ9.3), which is common in Chinese, is a new susceptibility factor for CD in China. Larger screening and genetic studies are needed in the Chinese population of different regions.

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