• Chun-Pai Yang, Cheng-Chieh Lin, Chia-Ing Li, Chiu-Shong Liu, Wen-Yuan Lin, Kai-Lin Hwang, Sing-Yu Yang, Hsuan-Ju Chen, and Tsai-Chung Li.
• From the Department of Neurology, Kuang Tien General Hospital (C-PY); Department of Nutrition, Huang-Kuang University (C-PY); School of Medicine, College of Medicine, China Medical University (C-CL, C-IL, C-SL, W-YL); Department of Medical Research (C-CL, C-IL, C-SL); Department of Family Medicine, China Medical University Hospital (C-CL, C-SL, W-YL); Department of Public Health, Chung Shan Medical University (K-LH); Graduate Institute of Biostatistics, College of Public Health, China Medical University (S-YY, T-CL); Management Office for Health Data, China Medical University Hospital (H-JC); and Department of Healthcare Administration, College of Medical and Health Science, Asia University, Taichung, Taiwan (T-CL).
• Medicine (Baltimore). 2015 Oct 1; 94 (42): e1783e1783.

AbstractThis study aimed to examine whether poor glycemic control, measured by glycated hemoglobin A1C (HbA1c) and other cardiovascular risk factors, can predict diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes mellitus (DM).Patients aged ≥30 years with type 2 DM, enrolled in the National Diabetes Care Management Program, and free of DPN (n = 37,375) in the period 2002 to 2004 were included and followed up until 2011. The related factors were analyzed using Cox proportional hazards regression models.For an average follow-up of 7.00 years, 8379 cases of DPN were identified, with a crude incidence rate of 32.04/1000 person-years. After multivariate adjustment, patients with HbA1c levels 7 to 8%, 8 to 9%, 9 to 10%, and ≥10% exhibited higher risk of DPN (adjusted HR: 1.11 [1.04-1.20], 1.30 [1.21-1.40], 1.32 [1.22-1.43], and 1.62 [1.51-1.74], respectively) compared with patients with HbA1c level 6 to 7%. There was a significant linear trend in DPN incidence with increasing HbA1c (P < 0.001) and significant HRs of DPN for patients with HbA1c level ≥7%, blood pressure ≥130/85 mm Hg, triglycerides (TG) ≥150 mg/dL, high density of lipoprotein-cholesterol (HDL-C) <40 mg/dL in males and <50 mg/dL in females, low density of lipoprotein-cholesterol (LDL-C) ≥100 mg/dL, and estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m.Patients with type 2 DM and HbA1c ≥7.0% exhibit increased risk of DPN, demonstrating a linear relationship. The incidence of DPN is also associated with poor glucose control and cardiovascular risk factors like hypertension, hyper-triglyceridemia, low HDL-C, high LDL-C, and decreased eGFR.

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