• Zhaowei Meng, Ming Liu, Qing Zhang, Li Liu, Kun Song, Jian Tan, Qiang Jia, Guizhi Zhang, Renfei Wang, Yajing He, Xiaojun Ren, Mei Zhu, Qing He, Shen Wang, Xue Li, Tianpeng Hu, Na Liu, Arun Upadhyaya, Pingping Zhou, and Jianping Zhang.
• From the Department of Nuclear Medicine (ZM, JT, QJ, GZ, RW, YH, SW, XL, TH, NL, AU, PZ, JZ), Department of Endocrinology and Metabolism (ML, XR, MZ, QH), and Department of Health Management, Tianjin Medical University General Hospital, Tianjin, P.R. China (QZ, LL, KS).
• Medicine (Baltimore). 2015 Dec 1; 94 (50): e2193e2193.

AbstractThe relationship between thyroid dysfunction and metabolic syndrome (MS) is complex. We aimed to explore the impact of gender and age on their association in a large Chinese cohort. This cross-sectional study enrolled 13,855 participants (8532 male, 5323 female), who self-reported as healthy without any known previous diseases. Clinical data including anthropometric measurements, thyroid function, and serum metabolic parameters were collected. The associations between thyroid function and MS of both genders were analyzed separately after dividing thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and age into subgroups. MS risks were calculated by binary logistic regression models. Young males had significantly higher MS prevalence than females, yet after menopause, females had higher prevalence than males. Females had higher incidence of thyroid dysfunction than males. By using TSH quartiles as the categorical variables and the lowest quartile as reference, significantly increased MS risk was demonstrated in quartile 4 for males, yet quartiles 3 and 4 for females. By using FT3 quartiles as the categorical variables, significantly increased MS risk was demonstrated in quartile 2 to 4 for females only. By using age subgroups as the categorical variables, significantly increased MS risk was shown in both genders, with females (4.408-58.455) higher than males (2.588-4.943). Gender and age had substantial influence on thyroid function and MS. Females with high TSH and high FT3 had higher MS risks than males. Aging was a risk for MS, especially for females. Urgent need is necessary to initiate interventional programs.

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