• Medicine · Dec 2017

    Correlation between resistin gene polymorphism and clinical aspects of lung cancer.

    • Wei-Wei Hu, Chih-Hsin Tang, Yi Sun, Ting-Ting Lu, Pu Jiang, Yue-Ming Wu, Chao-Qun Wang, Shun-Fa Yang, and Chen-Ming Su.
    • Department of Thoracic Surgery, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China Graduate Institute of Basic Medical Science, China Medical University Department of Biotechnology, College of Health Science, Asia University, Taichung, Taiwan Department of Biomedical Sciences Laboratory Department of Pathology, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China Department of Medical Research, Chung Shan Medical University Hospital Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
    • Medicine (Baltimore). 2017 Dec 1; 96 (52): e9485e9485.

    AbstractLung cancer is one of the most common cancers and is associated with a poor survival rate in the Chinese Han population. Analysis of genetic variants could lead to improvements in prognosis following lung cancer treatment. Resistin (RETN) is an important mediator of metabolic diseases and tumor progression. In this study, we explored the effects of RETN single nucleotide polymorphisms (SNPs) on the susceptibility and clinicopathological characteristics of patients with lung cancer. Four RETN SNPs (rs7408174, rs1862513, rs3745367, and rs3219175) were analyzed using TaqMan SNP genotyping in 371 patients with lung cancer and 451 cancer-free controls. The results showed that the RETN SNP rs3219175 with AG or at least 1 A allele was associated with a higher risk of lung cancer than wild-type (GG) carriers. Moreover, the RETN SNP rs3219175 with AG or AG + AA alleles was associated with a higher risk of distant metastasis than that in patients carrying GG alleles. We also used genotype-tissue expression datasets to compare the correlation of the RETN SNP rs3219175 in lung tissue and whole blood. In conclusion, our study demonstrated, for the first time, that RETN polymorphisms were correlated with lung cancer progression in the Chinese Han population.Copyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.

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