• Yan-Hong Pan, Yan-Mei Huang, Yong-Chao Qiao, Wei Ling, Li-Jun Geng, Jian-Long Xiao, Xiao-Xi Zhang, and Hai-Lu Zhao.
• Center for Diabetic Systems Medicine, Guangxi Key Laboratory of Excellence Institute of Basic Medical Sciences Department of Immunology, Guangxi Area of Excellence, Faculty of Basic Medicine, Guilin Medical University, Guilin Department of Immunology, School of Basic Medicine, Central South University, Changsha, Hunan, China.
• Medicine (Baltimore). 2017 Dec 1; 96 (51): e9148e9148.

AbstractA positive family history is recognized as an important risk factor for type 2 diabetes mellitus (T2DM), but the association of family history with rennin-angiotensin system (RAS) gene polymorphisms has not been reported yet, thus we aim to investigate it.Family history records, clinical and biochemical data were obtained from 1239 T2DM patients. Polymerase chain reaction (PCR) was performed for angiotensin-converting enzyme (ACE) genotyping and PCR-restricted fragment length polymorphism was used for angiotensinogen (AGT) genotyping.Patients with a negative family history had higher level of triglyceride and blood pressure, whereas those with a positive family history showed younger onset age and lower body mass index value (All P < .05), these findings were age-dependent. The percentage of hypertension was lower with a higher percentage of overweight among the patients with a positive family history (All P < .05). Patients with a positive family history and those with a negative family history had comparable genotype and allele distribution of ACE gene insertion/deletion polymorphisms and AGT gene M/T polymorphisms.A positive family history of diabetes was not associated with the RAS gene polymorphisms.Copyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.

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