• Medicine · Dec 2017

    Review Meta Analysis

    Efficacy of Lactobacillus reuteri DSM 17938 for infantile colic: Systematic review with network meta-analysis.

    • Pedro Gutiérrez-Castrellón, Flavia Indrio, Alexis Bolio-Galvis, Carlos Jiménez-Gutiérrez, Irma Jimenez-Escobar, and Gabriel López-Velázquez.
    • Center for Translational Research on Early Programming Nutrition and Mother-Child Nutrition, Hospital General Dr Manuel Gea González & Dirección de Investigación. Universidad Tecnológica de México-Unitec México University of Bari, Bari, Italy Universidad Tecnológica de México-Unitec, México Center for Analysis on Health Evidence, Hospital General Dr. Manuel Gea González Head of Medical Division, Hospital General Dr Manuel Gea González Genetic Biochemistry Department, Instituto Nacional de Pediatria.
    • Medicine (Baltimore). 2017 Dec 1; 96 (51): e9375e9375.

    Background5% to 40% of infants cry excessively, usually accompanied by fussiness and excessive of gas. There are no uniform criteria for treatment of infantile colic. Lactobacillus reuteri DSM 17938 has been used with promising results. The objective of this network-meta-analysis (NMA) is to compare the efficacy of L reuteri DSM 17938 with other interventions for infantile colic.MethodsRCTs, published between 1960 and 2015 for the treatment of infantile colic were included. Primary outcome was duration of crying after 21 to 28 days of treatment. Different databases were searched. Information was analyzed using control group as central axis. A random effect model was used. Hedges standard mean difference (SMD) and odds ratio (OR) were calculated. A SUCRA analysis was performed to evaluate superiority for each intervention.Results32 RCTs were analyzed, including 2242 patients. Studies with L reuteri DSM 17938 versus Ctrl., Diet versus Ctrl. and Acupuncture versus Ctrl. were the most influential studies in the NMA. L reuteri DSM 17938 [WMD -51.3 h (CI95% -72.2 to -30.5 h), P .0001] and dietetic approaches [WMD -37.4 h (CI95% -56.1 to -18.7 h), P .0001] were superior compared to the other treatments.ConclusionsL reuteri DSM 17938 and some dietetic approaches are better to other interventions for treatment of infantile colic.Copyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.

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