• Medicine · Feb 2018

    Meta Analysis

    Quantitative assessment of the relationship between Fas/FasL genes polymorphisms and head and neck cancer risk.

    • Dan-Feng Zhang, Guang-Bin Jiang, Chuan-Qi Qin, De-Xi Liu, Ya-Jun Hu, Juan Zhou, and Yu-Ming Niu.
    • Center for Evidence-Based Medicine and Clinical Research, Department of Endocrine Vascular Surgery, Taihe Hospital, Shiyan Department of Radiology, Suizhou Central Hospital, Suizhou The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine, Ministry of Education, Department of Oral and Maxillofacial Surgery, School & Hospital of Stomatology, Wuhan University, Wuhan Center for Evidence-Based Medicine and Clinical Research, Department of Stomatology, Taihe Hospital, Shiyan, China.
    • Medicine (Baltimore). 2018 Feb 1; 97 (6): e9873e9873.

    BackgroundMolecular epidemiological studies have demonstrated a closer association between Fas/FasL polymorphisms and head and neck cancer (HNC) risk, and the results of these published studies were inconsistent. We therefore performed this meta-analysis to explore the associations between Fas/FasL polymorphisms and HNC risk.MethodsFour online databases (PubMed, Embase, CNKI, and Wanfang) were searched. Odds ratios (ORs) with 95% confidence interval (95% CIs) were calculated to assess the association between Fas -670A>G, Fas -1377G>A, and FasL -844C>T polymorphisms and HNC risk. In addition, heterogeneity, accumulative/sensitivity analysis, and publication bias were conducted to check the statistical power.ResultsOverall, 9 related publications (20 independent case-control studies) involving 3179 patients and 4217 controls were identified. Significant association of protective effects was observed between FasL -844C>T polymorphism and HNC risk in codominant and dominant model models (CT vs CC: OR = 0.89, 95% CI = 0.79-1.00, P = .05, I = 38.3%, CT+TT vs CC: OR = 0.88, 95% CI = 0.79-0.98, P = .02, I = 35.8%). Furthermore, the similar protective effects were observed the subgroup analysis of in Asian population and population-based controls group.ConclusionOur meta-analysis indicated that FasL -844C>T polymorphism plays a protective role against HNC development, but the Fas -670A>G and Fas -1377G>A polymorphisms maybe not associated with HNC risk.

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