• Medicine · Dec 2014

    Case Reports

    Can thymidine phosphorylase be a predictive marker for gemcitabine and doxifluridine combination chemotherapy in cholangiocarcinoma?: case series.

    • Myoung Hee Kang, Won Sup Lee, Se-Il Go, Moon Jin Kim, Un Seok Lee, Hye Jung Choi, Dong Chul Kim, Jeong-Hee Lee, Hoon-Gu Kim, Kyung Soo Bae, and Jae Min Cho.
    • From the Department of Internal Medicine (MHK, WSL, S-IG, MJK, USL, HJC, H-GK); Department of Pathology (DCK, J-HL); and Department of Surgery, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, South Korea (KSB, JMC).
    • Medicine (Baltimore). 2014 Dec 1; 93 (28): e305e305.

    AbstractUnresectable cholangiocarcinoma is poorly responded to chemotherapy, especially for the case refractory to gemcitabine and cisplatin. Here, we tested whether high expression of thymidine phosphorylase (TP) can be a predictive biomarker for the indicator for gemcitabine and doxifluridine combination chemotherapy in the cholangiocarcinoma refractory to gemcitabine and cisplatin. Immunohistochemical staining for TP was performed with a biopsy specimen. We accepted the result as positive when more than 10% of cancer cells were stained with moderate intensity. Here, we report 2 cases of TP-positive cholangiocarcinoma well controlled with gemcitabine and doxifluridine combination chemotherapy, which had been refractory to the first line treatment with gemcitabine and cisplatin combination chemotherapy.

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