• Harun Düğeroğlu and Murat Özgenoğlu.
• MD. Assistant Professor, Department of Internal Medicine, Ordu Üniversitesi Tıp Fakültesi, Ordu, Turkey. Formerly at Van Yüzüncü Yıl Üniversitesi.
• Sao Paulo Med J. 2019 Aug 8; 137 (3): 278283278-283.

BackgroundGestational trophoblastic diseases (GTDs) are treatable rare tumors with wide distribution. The estimated incidence of GTDs varies dramatically between different regions globally. In early pregnancy, there may be high human chorionic gonadotropin (HCG) concentrations, normal or slightly increased free T4 (fT4) and subnormal thyroid-stimulating hormone (TSH), causing hyperthyroidism ranging from subclinical to severe. Beta-HCG causes thyrotoxicosis through thyroid stimulation in patients with trophoblastic tumors.ObjectiveTo assess thyroid function among patients diagnosed with complete or partial hydatidiform mole, within the GTD spectrum.Design And SettingCross-sectional study based on patients' medical records at Van University Hospital, Van, Turkey.Methods50 patients monitored due to diagnoses of hydatidiform mole were included and were examined regarding thyroid function. Thyroid gland size and volume were measured using thyroid ultrasonography. Beta-HCG, TSH, fT4, free T3 (fT3), total T4 (TT4), total T3 (TT3), anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (anti-TG) and thyroglobulin levels were measured.ResultsAmong these patients, 15 (30%) were diagnosed with complete hydatidiform mole and 35 (70%) with partial hydatidiform mole, according to pathology results. Those with complete hydatidiform mole were older (P = 0.003), with higher number of pregnancies (P = 0.032), lower TSH level (P = 0.011) and higher fT4 and TT4 levels (P = 0.04; P = 0.028), compared with partial hydatidiform mole patients.ConclusionIn hydatidiform mole patients, thyroid disease severity increases with age, parity, beta-HCG level and mole size. However, prospective multicenter studies on this topic are needed, with larger numbers of patients and closer monitoring.

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