• Sahar Saraf-Bank, Alireza Ahmadi, Zamzam Paknahad, Mohammadreza Maracy, and Mojgan Nourian.
• MSc. Doctoral Student and Dietitian, Students' Research Committee, Isfahan University of Medical Sciences; Doctoral Student and Dietitian, Food Security Research Center, Isfahan University of Medical Sciences; and Doctoral Student and Dietitian, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
• Sao Paulo Med J. 2019 Sep 1; 137 (5): 414422414-422.

BackgroundObese adolescents are at higher risk of development of cardiovascular risk factors and obesity in later life. Dietary intake of antioxidants, particularly curcumin, as an active ingredient of turmeric extract, may have noticeable effects on obesity and its important complications such as cardiovascular risk factors. Therefore, the aim of this study was to assess the effects of curcumin supplementation on cardiovascular risk factors among overweight and obese female adolescents.Design And SettingRandomized placebo-controlled clinical trial; Pediatric Cardiovascular Research Center, Isfahan, Iran.Methods60 adolescent girls (aged 13-18 years) were randomly assigned to receive either placebo or intervention. The adolescents were asked to consume one 500 mg tablet per day, containing either standardized 95% turmeric extract or placebo, and to undergo a weight maintenance or a mild weight loss diet for 10 weeks. Anthropometric and biochemical indices were assessed at the baseline and the end of the intervention.ResultsCurcumin supplementation had beneficial effects on body mass index (P = 0.019), waist circumference (P = 0.008), hip circumference (P = 0.030), high-density lipoprotein levels (P = 0.042) and triglyceride/high-density lipoprotein ratio (P = 0.021). However, in univariate analysis of covariance, no significant differences were found between the intervention and placebo groups after 10 weeks of supplementation (P > 0.05).ConclusionsPrescription of curcumin supplementation along with use of a slight weight loss diet might have beneficial effects on some cardiovascular risk factors among overweight and obese female adolescents. Larger clinical trials with higher curcumin doses and longer duration are needed to confirm the results from the current study.Clinical Trial RegistrationIRCT20171107037302N1.

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