• Hannah N Haq, Hafiz Khan, Haroon Chaudhry, Swathi Nimmala, Joseph Demidovich, Bhavani Nagendra Papudesi, and Sai Deepika Potluri.
• Department of Medicine, All Saints University, School of Medicine, Roseau, Dominica. Electronic address: hannahnaveenbanks@yahoo.com.
• J Natl Med Assoc. 2022 Dec 1; 114 (6): 601612601-612.

AbstractThe SARS-CoV-2 Virus (COVID-19) is responsible for over 239 million cases and 4.8 million deaths globally (Data source WHO COVID-19 Dashboard accessed on October 14, 2021). It continues to surge and ravage countries, leaving healthcare systems in constant struggle and uncertainty. A variety of vaccines were developed to combat the spread of the COVID-19 Virus. Reports of possible allergic reactions with COVID-19 vaccines are a significant cause of public concern, especially among those with a known history of a severe allergic reaction (e.g., anaphylaxis). Here we review articles relevant to COVID-19 vaccines and their excipients (especially PEG (Polyethylene glycol) and hypersensitivity reactions associated with COVID-19 vaccines (including clinical features, pathophysiology, special populations receiving COVID-19 vaccinations, potential diagnostic tests, and preventive measures that can be taken to minimize the risks of hypersensitivity reactions with COVID-19 vaccines).Copyright © 2022 National Medical Association. Published by Elsevier Inc. All rights reserved.

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