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Case Reports
Usefulness of Dapagliflozin for Nephrotic Syndrome Secondary to Diabetic Kidney Disease.
- Ryoko Murashima, Eiryu Sai, Yumi Tagawa, Hiroyuki Yanagawa, Sayaki Ishiwata, Yuko Kawaguchi, Tadashi Miyazaki, and Katsumi Miyauchi.
- Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Japan.
- Intern. Med. 2022 Dec 15; 61 (24): 369937023699-3702.
AbstractAn 81-year-old woman with a medical history of type 2 diabetes mellitus and diabetic nephropathy was admitted with a diagnosis of multiple cerebellar infarctions. Proteinuria and leg edema were observed on the day after admission and diagnosed as nephrotic syndrome. Furosemide and spironolactone were started but showed no diuretic effect, and the renal function deteriorated. These agents were then replaced with dapagliflozin, which resulted in a positive diuretic effect and subsequent improvement of hypoalbuminemia and renal dysfunction. This case report demonstrates the utility of dapagliflozin for nephrotic syndrome to achieve a positive diuretic effect and improve hypoalbuminemia without deteriorating the renal function.
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