• Annals of surgery · May 2023

    Medical Assistance in Dying (MAiD) as a Source of Liver Grafts: Honouring the Ultimate Gift.

    • Samrat Ray, Alejandro Torres-Hernandez, Michael Sean Bleszynski, Catherine Parmentier, Ian McGilvray, Blayne Amir Sayed, Chaya Shwaartz, Mark Cattral, Anand Ghanekar, Gonzalo Sapisochin, Cynthia Tsien, Nazia Selzner, Leslie Lilly, Mamatha Bhat, Elmar Jaeckel, Markus Selzner, and Trevor W Reichman.
    • Ajmera Transplant Centre, Toronto General Hospital, University Health Network.
    • Ann. Surg. 2023 May 1; 277 (5): 713718713-718.

    ObjectiveTo report the clinical outcomes of liver transplants from donors after medical assistance in dying (MAiD) versus donors after cardiac death (DCD) and deceased brain death (DBD).Summary Background DataIn North America, the number of patients needing liver transplants exceeds the number of available donors. In 2016, MAiD was legalized in Canada.MethodsAll patients undergoing deceased donor liver transplantation at Toronto General Hospital between 2016 and 2021 were included in the study. Recipient perioperative and postoperative variables and donor physiological variables were compared among 3 groups.ResultsEight hundred seven patients underwent deceased donor liver transplantation during the study period, including DBD (n=719; 89%), DCD (n=77; 9.5%), and MAiD (n=11; 1.4%). The overall incidence of biliary complications was 6.9% (n=56), the most common being strictures (n=55;6.8%), highest among the MAiD recipients [5.8% (DBD) vs. 14.2% (DCD) vs. 18.2% (MAiD); P =0.008]. There was no significant difference in 1 year (98.4% vs. 96.4% vs. 100%) and 3-year (89.3% vs. 88.7% vs. 100%) ( P =0.56) patient survival among the 3 groups. The 1- and 3- year graft survival rates were comparable (96.2% vs. 95.2% vs. 100% and 92.5% vs. 91% vs. 100%; P =0.37).ConclusionWith expected physiological hemodynamic challenges among MAiD and DCD compared with DBD donors, a higher rate of biliary complications was observed in MAiD donors, with no significant difference noted in short-and long-term graft outcomes among the 3 groups. While ethical challenges persist, good initial results suggest that MAiD donors can be safely used in liver transplantation, with results comparable with other established forms of donation.Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

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