• Annals of surgery · May 2023

    Local/regional Recurrence Rates after Breast Conserving Therapy in Patients Enrolled in Legacy Trials of the Alliance for Clinical Trials in Oncology (AFT-01).

    • Jessica R Schumacher, Alyssa A Wiener, Caprice C Greenberg, Bret Hanlon, Stephen B Edge, Kathryn J Ruddy, Ann H Partridge, Jennifer G Le-Rademacher, Menggang Yu, David J Vanness, Dou-Yan Yang, Jeffrey Havlena, Carrie Strand, and Heather B Neuman.
    • Department of Surgery, University of Wisconsin School of Medicine and Public Health.
    • Ann. Surg. 2023 May 1; 277 (5): 841845841-845.

    ObjectiveWe sought to evaluate local/regional recurrence rates after breast-conserving surgery in a cohort of patients enrolled in legacy trials of the Alliance for Clinical Trials in Oncology and to evaluate variation in recurrence rates by receptor subtype.BackgroundMultiple randomized controlled trials have demonstrated equivalent survival between breast conservation and mastectomy, albeit with higher local/regional recurrence rates after breast conservation. However, absolute rates of local/regional recurrence have been declining with multi-modality treatment.MethodsData from 5 Alliance for Clinical Trials in Oncology legacy trials that enrolled women diagnosed with breast cancer between 1997 and 2010 were included. Women who underwent breast-conserving surgery and standard systemic therapies (n=4,404) were included. Five-year rates of local/regional recurrence were estimated from Kaplan-Meier curves. Patients were censored at the time of distant recurrence (if recorded as the first recurrence), death, or last follow-up. Multivariable Cox proportional hazards models were used to identify factors associated with time to local/regional recurrence, including patient age, tumor size, lymph node status, and receptor subtype.ResultsOverall 5-year recurrence was 4.6% (95% CI=4.0-5.4%). Five-year recurrence rates were lowest in those with ER+ or PR+ tumors (Her2+ 3.4% [95% CI 2.0-5.7%], Her2- 4.0% [95% CI 3.2-4.9%]) and highest in the triple-negative subtype (7.1% [95% CI 5.4-9.3%]). On multivariable analysis, increasing nodal involvement and triple-negative subtype were positively associated with recurrence ( P <0.0001).ConclusionsRates of local/regional recurrence after breast conservation in women with breast cancer enrolled in legacy trials of the Alliance for Clinical Trials in Oncology are significantly lower than historic estimates. This data can better inform patient discussions and surgical decision-making.Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

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