• Aaron J Fields, Stefan Dudli, Andrew Schrepf, Angie Kim, Bernice Pham, Estefania Gallego, Sandra Mendoza, Sharon B Meropol, Jessa Darwin, Gwendolyn Sowa, and Nam V Vo.
• Department of Orthopaedic Surgery, University of California, San Francisco, California, USA.
• Pain Med. 2023 Aug 4; 24 (Suppl 1): S71S80S71-S80.

AbstractThe Biospecimen Collection and Processing Working Group of the National Institutes of Health (NIH) HEAL Initiative BACPAC Research Program was charged with identifying molecular biomarkers of interest to chronic low back pain (cLBP). Having identified biomarkers of interest, the Working Group worked with the New York University Grossman School of Medicine, Center for Biospecimen Research and Development-funded by the Early Phase Pain Investigation Clinical Network Data Coordinating Center-to harmonize consortium-wide and site-specific efforts for biospecimen collection and analysis. Biospecimen collected are saliva, blood (whole, plasma, serum), urine, stool, and spine tissue (paraspinal muscle, ligamentum flavum, vertebral bone, facet cartilage, disc endplate, annulus fibrosus, or nucleus pulposus). The omics data acquisition and analyses derived from the biospecimen include genomics and epigenetics from DNA, proteomics from protein, transcriptomics from RNA, and microbiomics from 16S rRNA. These analyses contribute to the overarching goal of BACPAC to phenotype cLBP and will guide future efforts for precision medicine treatment.© The Author(s) 2022. Published by Oxford University Press on behalf of the American Academy of Pain Medicine.

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