• Intern Emerg Med · Mar 2023

    Serological response to COVID-19 pneumonia and increasing severity over 18 months in a prospective cohort of hospitalized patients.

    • Gemma Grau Gómez, Xavier Martínez Lacasa, Roser Costa, Bienvenido Barreiro, Miguel Leal, Emma Padilla, Pepa Pérez, Marc Garreta, Judith Vidal, Angeles Jaen, Helena Monzón Camps, and COMUTE Study Group (COVID-19 Mutua Terrassa Study Group).
    • Internal Medicine Department, Fundació Mútua Terrassa, Plaça del Doctor Robert, 5, 08221, Terrassa, Barcelona, Spain. gemma.grau27@gmail.com.
    • Intern Emerg Med. 2023 Mar 1; 18 (2): 397407397-407.

    AbstractIn this study, we present an 18-month serological follow-up of 294 patients with COVID-19 pneumonia. The aim was to assess the dynamics of serological response and its correlation with clinical worsening, as well as to describe clinical worsening determinants. Results of the study showed an early immunoglobulin M response, which clearly diminished starting at 4 months, but nonetheless, a small group of patients remained positive. As for immunoglobulin G, levels were higher up to 6 months in patients who presented clinical worsening during hospitalization. High titers of the immunoglobulin were maintained in all patients during follow-up, which would indicate that humoral immunity due to infection is long-lasting. Male sex, presence of myalgias and extensive radiological affectation were significantly correlated with clinical worsening.© 2022. The Author(s), under exclusive licence to Società Italiana di Medicina Interna (SIMI).

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