• Steven Marwaha, Edward Palmer, Trisha Suppes, Emily Cons, Allan H Young, and Rachel Upthegrove.
• Institute for Mental Health, University of Birmingham, Birmingham, UK; Birmingham and Solihull Mental Health NHS Trust, Birmingham, UK.
• Lancet. 2023 Jan 14; 401 (10371): 141153141-153.

AbstractDepression is common, costly, debilitating, and associated with increased risk of suicide. It is one of the leading global public health problems. Although existing available pharmacological treatments can be effective, their onset of action can take up to 6 weeks, side-effects are common, and recovery can require treatment with multiple different agents. Although psychosocial interventions might also be recommended, more effective treatments than those currently available are needed for people with moderate or severe depression. In the past 10 years, treatment trials have developed and tested many new targeted interventions. In this Review, we assess novel and emerging biological treatments for major depressive disorder, evaluate their putative brain and body mechanisms, and highlight how close each might be to clinical use.Copyright © 2023 Elsevier Ltd. All rights reserved.

17 keywords...

hide…