• Dominik T Steck, Srdjan Jelacic, Nicki Mostofi, David Wu, Lauren Wells, Christine T Fong, Kevin C Cain, Richard D Sheu, and Kei Togashi.
• Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA. Electronic address: dsteck@uw.edu.
• J. Cardiothorac. Vasc. Anesth. 2023 Mar 1; 37 (3): 374381374-381.

ObjectivesThe clinical significance of hypophosphatemia in cardiac surgery has not been investigated extensively. The aim of this study was to evaluate the association of postoperative hypophosphatemia and lactic acidosis in cardiac surgery patients at the time of intensive care unit (ICU) admission.DesignA retrospective cohort study.SettingAt a single academic center.ParticipantsPatients who underwent nontransplant cardiac surgery with cardiopulmonary bypass between August 2009 and December 2020.InterventionsNone.Measurements And Main ResultsSerum phosphate and lactate levels were measured upon ICU admission in patients undergoing nontransplant cardiac surgery with cardiopulmonary bypass. There were 681 patients in the low-phosphate (<2.5 mg/dL) group and 2,579 patients in the normal phosphate group (2.5-4.5 mg/dL). A higher proportion of patients in the low phosphate group (26%; 179 of 681; 95% CI: 23-30) had severe lactic acidosis compared to patients in the normal phosphate group (16%; 417 of 2,579; 95% CI: 15-18). In an unadjusted logistic regression model, patients in the low phosphate group had 1.9-times the odds of having severe lactic acidosis (serum lactate ≥4.0 mmol/L) when compared to patients in the normal phosphate group (95% CI: 1.5-2.3), and still 1.4-times the odds (95% CI: 1.1-1.7) after adjusting for several possible confounders.ConclusionsHypophosphatemia is associated with lactic acidosis in the immediate postoperative period in cardiac surgery patients. Future studies will need to investigate it as a potential treatment target for lactic acidosis.Copyright © 2022 Elsevier Inc. All rights reserved.

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