• Wen Gao, Bin Qin, Huixun Qin, Cheng Qin, Jiede Zhang, Yumin Liang, and Chao Qin.
• Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China; Department of Neurology, Liuzhou People's Hospital Affiliated to Guangi Medical University, Liuzhou, Guangxi, China.
• World Neurosurg. 2023 Mar 1; 171: 167174.e7167-174.e7.

ObjectiveAcute ischemic stroke (AIS) is a severe, life-threatening type of stroke with poor prognosis and high recurrence rate, mainly attributed to large vessel occlusion (LVO). Improved understanding of the safety and effectiveness of the Soft Torqueable Catheter Optimized For Intracranial Access (SOFIA) for LVO-AIS might guide practitioners. Therefore, we conducted this study focusing on neurological outcomes, procedure-related complications, and recanalization rates.MethodsWe collected data in January 2022 from PubMed, Cochrane, Web of Science, and Embase. The study considered that assessed the effects of the SOFIA catheter in treatment of LVO-AIS. We extracted data narratively and expressed the results with the proportions and 95% confidence intervals (CI).ResultsWe included 17 studies reporting on 2106 patients treated with the SOFIA catheter. The successful recanalization rate was 77% (95% CI, 71%-83%) with the SOFIA catheter alone and the application of a rescue stent-retriever was observed in 28% (95% CI, 23%-33%) of cases, resulting in an overall successful recanalization rate of 90% (95% CI, 87%-92%). A pooled estimate of 45% (95% CI, 39%-51%) was observed for functional independence at 90 days, 15% (95% CI, 11%-20%) for mortality at 90 days, and 5% (95% CI, 3%-8%) for symptomatic intracranial hemorrhage.ConclusionsThis meta-analysis revealed that aspiration thrombectomy with the SOFIA catheter is a safer and effective treatment modality for LVO-AIS.Copyright © 2022 Elsevier Inc. All rights reserved.

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