• Jae-Won Lee, Hun-Chul Kim, Sang-Il Kim, Hyung-Ki Min, Kee-Yong Ha, Hyung-Youl Park, Chang-Hee Cho, Hoon-Seok Sung, Jae-Hak Lim, and Young-Hoon Kim.
• Department of Orthopedic Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
• World Neurosurg. 2023 Mar 1; 171: e31e37e31-e37.

ObjectiveWe investigated the long-term effects of bone cement-augmented instrumentation in multilevel lumbar fusions in a retrospective cohort study. The use of cement-augmented screws is one of the techniques used to reduce early mechanical failure in treating multilevel lumbar fusion, especially in the elderly. However, little information is available regarding the long-term effects.MethodsA total of 51 patients who had undergone ≥3 levels of lumbar fusion were divided into two groups according to the use of bone cement-augmented screw fixation involving the upper instrumented vertebra: 22 patients in the cement-augmented group (group I) and 29 patients in the non-cement-augmented group (group II). Analysis of radiographic adjacent disc segment degeneration (ASD) revealed patients with lumbosacral fusion with a similar degree of osteoporosis. Radiologic ASD was defined as progression of >2 UCLA (University of California, Los Angeles) grades at 2 years postoperatively. Other sagittal parameters and the preoperative magnetic resonance imaging Pfirrmann grades at the adjacent levels, possibly related to ASD, were also analyzed.ResultsNo significant differences were present in the preoperative demographic and radiographic parameters between the 2 groups. However, the postoperative kyphotic changes at 3 months were greater for the non-cement-augmented group. In terms of the long-term effects, the incidence of radiologic ASD (group I, n = 20 [95.2%]; vs group II, n = 15 [53.6%]) was significantly higher in the cement-augmented group. Logistic regression analysis of radiologic ASD, including other clinical and radiologic parameters, postoperative pelvic incidence-lumbar lordosis mismatch (odds ratio, 5.201; 95% confidence interval, 1.123-24.090; P = 0.035), and cement augmentation (odds ratio, 20.193; 95% confidence interval, 2.195-185.729; P = 0.008) showed a significant correlation with the development of radiologic ASD at 2 years postoperatively.ConclusionsAlthough bone cement-augmented screw implantation can prevent kyphotic deformation at the proximal junction of upper instrumented vertebra in the early postoperative stages of multilevel lumbar fusion, a careful selection of patients is required because of possibly accelerated degeneration of adjacent segments.Copyright © 2022 Elsevier Inc. All rights reserved.

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