• Internal medicine · Aug 2023

    Case Reports

    Bullous Pemphigoid in X-linked Alport Syndrome: A Case Report.

    • Masahiro Yamawaki, Kan Katayama, Mika Fujimoto, Hiroyuki Goto, Hiroto Yuasa, Yuji Kozuka, Mutsuki Mori, Daisuke Takahashi, Ryosuke Saiki, Yosuke Hirabayashi, Tomohiro Murata, Keiichi Yamanaka, and Kaoru Dohi.
    • Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Japan.
    • Intern. Med. 2023 Aug 15; 62 (16): 237523792375-2379.

    AbstractSkin lesions in X-linked Alport syndrome (XLAS) are rarely observed. Bullous pemphigoid (BP) is caused by autoantibodies against BP180, also called α1 (XVII) chain, in the basement membrane zone (BMZ). A 48-year-old man with XLAS developed tense blisters. A skin biopsy showed a cleft between the basal cell layer and dermis, with the infiltration of neutrophils and eosinophils. α1 (XVII) staining was positive on the epidermal side of α2/5 (IV) staining. Oral prednisolone improved his symptoms gradually. Abundant tense blisters on the palms and soles might suggest an important role of the α5 (IV) chain in the integrity of BMZ.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…