• Jialin Mao, Christian-Alexander Behrendt, Michael O Falster, Ramon L Varcoe, Xinyan Zheng, Frederik Peters, Barry Beiles, Marc L Schermerhorn, Louisa Jorm, Adam W Beck, and Art Sedrakyan.
• Department of Population Health Sciences, Weill Cornell Medicine, New York, NY.
• Ann. Surg. 2023 Sep 1; 278 (3): e626e633e626-e633.

ObjectiveTo examine long-term outcomes after endovascular (EVAR) and open repairs (OAR) for intact abdominal aortic aneurysms in Australia, Germany, and the United States, using a unified study design.BackgroundSimilarities and differences in long-term outcomes after EVAR versus OAR across countries remained unclear, given differences in designs across existing studies.MethodsWe identified patients aged >65 years undergoing intact abdominal aortic aneurysm repairs during 2010-2017/2018. We compared long-term patient mortality and reintervention after EVAR and OAR using Kaplan-Meier analyses and Cox regressions. Propensity score matching was performed within each country to adjust for differences in baseline patient characteristics between procedure groups.ResultsWe included 3311, 4909, and 145363 patients from Australia, Germany, and the United States, respectively. The median patient age was 76 to 77 years, and most patients were males (77%-84%). Patient mortality was lower after EVAR than OAR within the first 60 days and became similar at 3-year follow-up (Australia 14.7% vs 16.5%, Germany 18.2% vs 19.7%, United States: 24.4% vs 24.4%). At the end of follow-up, patient mortality after EVAR was higher than OAR in Australia [ hazard ratio (HR) 95% CI: 1.21 (0.96-1.54)] but similar to OAR in Germany [HR 95% CI: 0.92 (0.80-1.07)] and the United States [HR 95% CI: 1.02 (0.99-1.05)]. The risk of reintervention after EVAR was more than twice that after OAR in Australia [HR 95% CI: 2.60 (1.09-6.15)], Germany [HR 95% CI: 4.79 (2.56-8.98)], and the United States [HR 95% CI: 2.67 (2.38-3.00)]. The difference in reintervention risk appeared early in German and United States patients.ConclusionsThis multinational study demonstrated important similarities in long-term outcomes after EVAR versus OAR across 3 countries. Variation in long-term mortality and reintervention comparisons indicates possible differences in patient profiles, surveillance, and best medical therapy across countries.Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

27 keywords...

hide…