• Kensuke Nakamura, Hidehiko Nakano, Daisuke Ikechi, Masaki Mochizuki, Yuji Takahashi, Yasuhiro Ogawa, Yujiro Matsuishi, Nobutake Shimojo, and Yoshiaki Inoue.
• Department of Emergency and Critical Care Medicine, Hitachi General Hospital, 2-1-1, Jonan-cho, Hitachi, Ibaraki 317-0077, Japan. Electronic address: mamashockpapashock@yahoo.co.jp.
• J Crit Care. 2023 Apr 1; 74: 154234154234.

PurposeWe hypothesized that coagulopathy independently contributes to muscle injury focusing to titin fragmentation, and investigated their correlations.Material And MethodsWe conducted a post-hoc analysis of an observational study, in which we evaluated muscle injury with the biomarker titin. Coagulopathy was assessed on the first day using the Japanese diagnostic criteria of acute-phase disseminated intravascular coagulopathy (JAAM-DIC). Mean N-titin/Cre measured on days 1, 3, 5, and 7 was assigned as the primary outcome.ResultsOverall, 111 eligible patients were included. Mean N-titin/Cre were significantly higher in the JAAM-DIC group. A multivariable analysis identified JAAM-DIC as independent risk factors for mean N-titin/Cre while other severity scores were not.ConclusionsCoagulopathy correlated with muscle titin fragmentation, as an independent risk factor.Trial Registration NumberThe present study is registered at the University Hospital Medical Information Network-clinical trials registry (UMIN000040290, Registration date: May 7, 2020).Copyright © 2022 Elsevier Inc. All rights reserved.

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