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Antimicrob. Agents Chemother. · Apr 2008
Powerful bactericidal and sterilizing activity of a regimen containing PA-824, moxifloxacin, and pyrazinamide in a murine model of tuberculosis.
- Eric Nuermberger, Sandeep Tyagi, Rokeya Tasneen, Kathy N Williams, Deepak Almeida, Ian Rosenthal, and Jacques H Grosset.
- Center for Tuberculosis Research, Johns Hopkins University, Baltimore, Maryland, USA. enuermb@jhmi.edu
- Antimicrob. Agents Chemother. 2008 Apr 1;52(4):1522-4.
AbstractPA-824 is a nitroimidazo-oxazine in clinical testing for the treatment of tuberculosis. We report that the novel combination of PA-824, moxifloxacin, and pyrazinamide cured mice more rapidly than the first-line regimen of rifampin, isoniazid, and pyrazinamide. If applicable to humans, regimens containing this combination may radically shorten the treatment of multidrug-resistant tuberculosis.
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