• Aaron Nathan BarksdaleDepartment of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE, United States of America. Electronic address: aaron.barksdale@unmc.edu., Macy G Wood, Chad E Branecki, Brooklin Zimmerman, Elizabeth Lyden, Thang T Nguyen, Andrew Hatfield, Scott Koepsell, Jason Langenfeld, Wesley G Zeger, and Michael C Wadman.
• Department of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE, United States of America. Electronic address: aaron.barksdale@unmc.edu.
• Am J Emerg Med. 2022 Dec 14; 64: 155160155-160.

IntroductionIn United States, health care workers have been immersed in the COVID-19 pandemic since February 2020. Since availability of COVID-19 vaccines, there is limited literature investigating the incidence of unknown COVID-19 infections in physicians and Advanced Practitioner Providers (APPs) working in emergency departments (EDs). The primary objective is to determine the incidence unknown COVID-19 infection within a cohort of emergency physicians (EPs) and APPs.MethodsProspective observational study at a tertiary academic center with emergency medicine residency and 64,000 annual ED visits. EPs/APPs providing care to ED patients over the prior 12 months were eligible. Serum samples were collected between May 1 and June 30, 2022. Analysis utilized Luminex xMAP® SARS-CoV-2 Multi-Antigen IgG Assay for antibodies to Nucleocapsid, Receptor-binding domain, and Spike subunit 1. Mean Fluorescent Intensity (MFI) ≥ 700 was considered positive. Subjects completed 12 question survey assessing demographics and previously confirmed COVID-19 infection. Fisher's exact test evaluated associations of demographics and clinical characteristics with confirmed COVID-19 status. Analyses performed using SAS, Version 9.4. P < 0.05 considered statistically significant.ResultsSixty-nine of 81 eligible subjects (85.2%) participated, 58.0% were male, 97.1% white, with mean age of 37. Eighteen subjects had MFI ≥ 700 strongly suggestive of prior infection, with 17.7% unknown. No statistically significant difference between age, gender, race, children in home, or household member with previously COVID-19 infection.ConclusionUnknown previous COVID-19 infection was less then expected in this cohort of EPs/APPs, and no association with individual characteristics, previously infected household member, or children in the home.Copyright © 2022 Elsevier Inc. All rights reserved.

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