• MeyerMartin Abild StengaardMASDepartment of Cardiology, The Heart Center, Copenhagen University Hospital, Rigshospitalet, Denmark. Electronic address: martin.abild.stengaard.meyer@regionh.dk., Mette Bjerre, Sebastian Wiberg, Johannes Grand, OblingLaust Emil RoelsgaardLERDepartment of Cardiology, The Heart Center, Copenhagen University Hospital, Rigshospitalet, Denmark., MeyerAnna Sina PetterssonASPDepartment of Cardiology, The Heart Center, Copenhagen University Hospital, Rigshospitalet, Denmark., Jakob Josiassen, Martin Frydland, ThomsenJakob HartvigJHDepartment of Cardiology, The Heart Center, Copenhagen University Hospital, Rigshospitalet, Denmark., Ruth Frikke-Schmidt, Jesper Kjaergaard, and Christian Hassager.
• Department of Cardiology, The Heart Center, Copenhagen University Hospital, Rigshospitalet, Denmark. Electronic address: martin.abild.stengaard.meyer@regionh.dk.
• Resuscitation. 2023 Mar 1; 184: 109676109676.

AimTo investigate how the inflammatory response after out-of-hospital cardiac arrest (OHCA) is modulated by blocking IL-6-mediated signalling with tocilizumab, and to relate induced changes to clinical status, myocardial- and brain injury.MethodsThis is a preplanned substudy of the IMICA trial (ClinicalTrials.gov, NCT03863015). Upon admission 80 comatose OHCA patients were randomized to infusion of tocilizumab or placebo. Inflammation was characterized by a cytokine assay, CRP, and leukocyte differential count; myocardial injury by TnT and NT-proBNP; brain injury by neuron-specific enolase (NSE) and Neurofilament Light chain (NFL), while sequential organ assessment (SOFA) score and Vasoactive-Inotropic Score (VIS) represented overall clinical status.ResultsResponses for IL-5, IL-6, IL-17, neutrophil as well as monocyte counts, and VIS were affected by tocilizumab treatment (all p < 0.05), while there was no effect on levels of NFL. IL-5 and IL-6 were substantially increased by tocilizumab, while IL-17 was lowered. Neutrophils and monocytes were lower at 24 and 48 hours, and VIS was lower at 24 hours, for the tocilizumab group compared to placebo. Multiple correlations were identified for markers of organ injury and clinical status versus inflammatory markers; this included correlations of neutrophils and monocytes with TnT, NSE, NFL, SOFA- and VIS score for the tocilizumab but not the placebo group. NT-proBNP, NFL and SOFA score correlated with CRP in both groups.ConclusionsTreatment with tocilizumab after OHCA modulated the inflammatory response with notable increases for IL-5, IL-6, and decreases for neutrophils and monocytes, as well as reduced vasopressor and inotropy requirements.Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.

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