• Internal medicine · Mar 2023

    Review Case Reports

    Relapsing Anti-MOG Antibody-associated Disease Following COVID-19 Vaccination: A Rare Case Report and Review of the Literature.

    • Hiroto Nakano, Kazuyoshi Yamaguchi, Naoyuki Hama, Yasuko Matsumoto, Moeko Shinohara, and Hisashi Ide.
    • Department of Neurology, Ishikawa Prefectural Central Hospital, Japan.
    • Intern. Med. 2023 Mar 15; 62 (6): 923928923-928.

    AbstractAnti-myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an autoimmune demyelinating disorder that mainly occurs post-infection or post-vaccination. MOGAD after inoculation with coronavirus disease 2019 (COVID-19) vaccines is rare, and we herein report a rare case of a patient with MOGAD after vaccination using the Pfizer-BioNTech COVID-19 vaccine (BNT162b2, Pfizer Japan, Tokyo). Our report highlights the fact that MOGAD following inoculation with COVID-19 vaccine may show clinical relapse during reduction of the oral steroid dose, and continuous treatments with immunological agents is needed to prevent disease recurrence.

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