• Internal medicine · Sep 2023

    Case Reports

    Ulcerative Colitis-associated Spondyloarthritis Successfully Treated with Infliximab in the Absence of Enhanced TNF-α Responses.

    • Shunsuke Fujita, Hajime Honjo, Ryutaro Takada, Akane Hara, Yasuhiro Masuta, Yasuo Otsuka, Kohei Handa, Kosuke Minaga, Shigeyoshi Tsuji, Masatoshi Kudo, and Tomohiro Watanabe.
    • Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan.
    • Intern. Med. 2023 Sep 1; 62 (17): 249324972493-2497.

    AbstractAlthough concurrent occurrence of spondyloarthritis (SpA) and ulcerative colitis (UC) is sometimes seen, the profiles of cytokines have been poorly understood in UC-associated SpA. We herein report a case of UC-associated SpA successfully treated with infliximab (IFX). Profiles of cytokines in the serum and colonic mucosa were characterized by an enhanced expression of IL-6 but not tumor necrosis factor (TNF)-α. Successful induction of remission by IFX was associated with the downregulation of IL-6 expression but no significant alteration in TNF-α expression. These findings suggest that some cases of UC-associated SpA might be driven by IL-6, and IFX might be effective in cases lacking enhanced TNF-α responses.

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