• Yelitza Vega-de LoPresti, Elimar Montilva-Gutiérrez, Alejandro Valenzuela-Vegas, Karelis E Salazar-Pérez, Andrea S Paredes-Manodanda, Allan J Alvarado-García, Anny E González-Zarraga, Yudith K Suárez-Osorio, Marialejandra Mendoza, Carmen E Altamiranda, Cleizer Altamiranda, Yamile L Aparicio-de Marín, Roald Gómez, Vanessa Villarreal, Zoujair Salmen, and Siham Salmen.
• Pulmonology Department, Instituto Autónomo Hospital Universitario de Los Andes.
• Gac Med Mex. 2022 Jan 1; 158 (5): 310316310-316.

IntroductionThere are aspects of COVID-19 pathogenesis that are still unknown.ObjectiveTo determine the relationship between severity, mortality and viral replication in patients with COVID-19.MethodsClinical characteristics, severity and mortality of 203 patients hospitalized for COVID-19 were analyzed and correlated with viral load (VL) and threshold cycle (TC) at admission; nasopharyngeal swab was obtained.ResultsMean VLs in surviving patients with mild to moderate, moderate to severe and severe disease were the following: 6.8 x 106, 7.6 x 107 and 1.0 x 109, respectively; and in patients with critical disease who died, VL was 1.70 x 109. TCs were 26.06, 24.07, 22.66 and 21.78 for the same groups. In those who died, a higher mean VL was observed at admission in comparison with those who survived (1.7 x 109 vs. 9.84 x 106; p < 0.001). A significant correlation was observed between VL, severity and death (r = 0.254, p < 0.045 and r = 0.21, p < 0.015). High VL was associated with increased in-hospital mortality in comparison with low VL (OR = 2.926, p < 0.017).ConclusionSARS-CoV-2 VL determined at hospital admission might classify risk simultaneously with other factors described in COVID-19.Copyright: © 2022 Permanyer.

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