• Regis Goulart Rosa, Alexandre Biasi Cavalcanti, AzevedoLuciano César PontesLCPBrazilian Research in Intensive Care Network (BRICNet), São Paulo, SP, Brazil.Hospital Sírio-Libanês, São Paulo, SP, Brazil., Viviane Cordeiro Veiga, Denise de Souza, Rosa da Rosa Minho Dos Santos, Raíne Fogliati de Carli Schardosim, Gabriela Soares Rech, Geraldine Trott, Daniel Schneider, Caroline Cabral Robinson, Tainá Aparecida Haubert, Victoria Emanuele Lobo Pallaoro, Liége Gregoletto Brognoli, Ana Paula de Souza, Lauren Sezerá Costa, Bruna Machado Barroso, Melissa Pezzetti Pelliccioli, Janine Gonzaga, Nicole Dos Santos Studier, Ana Paula Aquistapase Dagnino, Juliana de Mesquita Neto, Sabrina Souza da Silva, Bruna Dos Passos Gimenes, Vanessa Brzoskowski Dos Santos, Gabriel Pozza Muller Estivalete, Carolina de Moraes Pellegrino, Carisi Anne Polanczyk, Letícia Kawano-Dourado, TomaziniBruno MartinsBMBrazilian Research in Intensive Care Network (BRICNet), São Paulo, SP, Brazil.Hcor Research Institute, Hospital Do Coração, São Paulo, SP, Brazil.Hospital Sírio-Libanês, São Paulo, SP, Brazil., Thiago Costa Lisboa, Cassiano Teixeira, Fernando Godinho Zampieri, Alexandre Prehn Zavascki, Bernard J Gersh, Álvaro Avezum, Flávia Ribeiro Machado, Otavio Berwanger, Renato Delascio Lopes, and Maicon Falavigna.
• Hospital Moinhos de Vento, Rua Ramiro Barcelos, 630, 10º Andar, Sala 1007, Porto Alegre, RS, 90660-020, Brazil. regisgoulartrosa@gmail.com.
• Intensive Care Med. 2023 Feb 1; 49 (2): 166177166-177.

PurposeTo assess the association between acute disease severity and 1-year quality of life in patients discharged after hospitalisation due to coronavirus disease 2019 (COVID-19).MethodsWe conducted a prospective cohort study nested in 5 randomised clinical trials between March 2020 and March 2022 at 84 sites in Brazil. Adult post-hospitalisation COVID-19 patients were followed for 1 year. The primary outcome was the utility score of EuroQol five-dimension three-level (EQ-5D-3L). Secondary outcomes included all-cause mortality, major cardiovascular events, and new disabilities in instrumental activities of daily living. Adjusted generalised estimating equations were used to assess the association between outcomes and acute disease severity according to the highest level on a modified ordinal scale during hospital stay (2: no oxygen therapy; 3: oxygen by mask or nasal prongs; 4: high-flow nasal cannula oxygen therapy or non-invasive ventilation; 5: mechanical ventilation).Results1508 COVID-19 survivors were enrolled. Primary outcome data were available for 1156 participants. At 1 year, compared with severity score 2, severity score 5 was associated with lower EQ-5D-3L utility scores (0.7 vs 0.84; adjusted difference, - 0.1 [95% CI - 0.15 to - 0.06]); and worse results for all-cause mortality (7.9% vs 1.2%; adjusted difference, 7.1% [95% CI 2.5%-11.8%]), major cardiovascular events (5.6% vs 2.3%; adjusted difference, 2.6% [95% CI 0.6%-4.6%]), and new disabilities (40.4% vs 23.5%; adjusted difference, 15.5% [95% CI 8.5%-22.5]). Severity scores 3 and 4 did not differ consistently from score 2.ConclusionsCOVID-19 patients who needed mechanical ventilation during hospitalisation have lower 1-year quality of life than COVID-19 patients who did not need mechanical ventilation during hospitalisation.© 2022. Springer-Verlag GmbH Germany, part of Springer Nature.

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