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Clin. Pharmacol. Ther. · Feb 2015
Opioids for chronic noncancer pain: still no evidence for superiority of sustained-release opioids.
- L Pedersen and Oms Fredheim.
- National Competence Centre for Complex Symptom Disorders, Trondheim, Norway; Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway; Department of Internal Medicine, Sørlandet Hospital Kristiansand, Kristiansand, Norway.
- Clin. Pharmacol. Ther. 2015 Feb 1;97(2):114-5.
AbstractOpioids are controversial in the treatment of chronic pain due to the risk of addiction, misuse, and death. Long-acting formulations of opioids have been hypothesized to improve pain relief, sleep quality, and lower the risk of side effects and addiction compared to short-acting formulations of opioids. Thus, several guidelines have recommended the use of long-acting opioid formulations over short-acting ones in the treatment of chronic noncancer pain. However, is there really evidence of their superiority?© 2014 ASCPT.
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