• Acta Anaesthesiol Scand · Apr 2023

    Observational Study

    Unresolved early postoperative pain trajectory predicts moderate-to-severe persistent pain after breast cancer surgery-An observational cohort study.

    • Damien Leblanc, Arthur Guichoux, Marjorie Sail, François Boré, Valérie Seegers, and Fabien Espitalier.
    • Department of Anaesthesia and Intensive Care, Angers University Hospital, Angers, France.
    • Acta Anaesthesiol Scand. 2023 Apr 1; 67 (4): 448454448-454.

    BackgroundModelling acute post-operative pain trajectories may improve the prediction of persistent pain after breast cancer surgery (PPBCS). This study aimed to investigate the predictive accuracy of early post-operative pain (EPOP) trajectories in the development of PPBCS.Materials & MethodsThis observational study was conducted in a French Comprehensive Cancer Centre and included patients who underwent breast cancer surgery from December 2017 to November 2018. Perioperative and follow-up data were obtained from medical records, and anaesthesia and perioperative charts. EPOP was defined as pain intensity during the first 24 h after surgery, and modelled by a pain trajectory. K-means clustering method was used to identify patient subgroups with similar EPOP trajectories. The prevalence of moderate-to-severe PPBCS (numeric rating scale ≥4) was evaluated until 24 months after surgery.ResultsA total of 608 patients were included in the study, of which 18% (n = 108) and 9% (n = 52) reported mild and moderate-to-severe PPBCS, respectively. Based on EPOP trajectories, we were able to identify a low (64%, n = 388), resolved (30%, n = 182), and unresolved (6%, n = 38) pain group. Multivariate analysis identified younger age, axillary lymph node dissection, and unresolved EPOP trajectory as independent risk factors for moderate-to-severe PPBCS development. When compared to patients reporting mild PPBCS, moderate-to-severe PPBCS patients experienced significantly more neuropathic pain features, pain-related interference, and delayed opioid cessation.ConclusionEPOP trajectories can distinguish between resolved and unresolved acute pain after breast cancer surgery, allowing early identification of patients at risk to develop significant PPBCS.© 2022 Acta Anaesthesiologica Scandinavica Foundation.

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